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KMID : 1123920180320050328
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Korean Journal of Oriental Physiology and Pathology
2018 Volume.32 No. 5 p.328 ~ p.332
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Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Nephrotoxicity in Mouse Model
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Oh Gi-Su
Lee Su-Bin
So Hong-Seob
Kim Ha-Rim
Lee Young-Rae
Lee Guem-San
Yang Sei-Hoon
Lim Chan-Han
Kwon Kang-Beom
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Abstract
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In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephrotoxicity and body weight decrease. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse model. We found that BSTE administration protected tubular injury by cisplatin in mouse model. BSTE also inhibited increase of creatinine and BUN induced by cisplatin injection in serum. Collectively, our data suggest that BSTE could be a therapeutic agent for reducing kidney injury induced by cisplatin treatment in cancer patients.
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KEYWORD
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Banhasasim-tang, Cisplatin, Nephrotoxicity, Cancer
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